4GDY

Kynurenine Aminotransferase II inhibitors

Summary for 4GDY

• Entry DOI: 10.2210/pdb4gdy/pdb
• Related: 3UE8 4GE4 4GE7 4GE9 4GEB
• Descriptor: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-6-methyl-4-{[(1-oxo-7-phenoxy-1,2-dihydro[1,2,4]triazolo[4,3-a]quinolin-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate (3 entities in total)
• Functional Keywords: aminotransferase, pyridoxal phosphate co-factor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion (Potential): Q8N5Z0
• Total number of polymer chains: 2
• Total formula weight: 98947.02

Authors

Pandit, J. (deposition date: 2012-08-01, release date: 2012-08-29, Last modification date: 2023-09-13)

• Primary citation: Verhoest, P.R.,Henderson, J.L.,Sawant-Basak, A.,Tuttle, J.B.,Dounay, A.B.,McAllister, L.A.,Pandit, J.,Rong, S.,Hou, X.,Bechle, B.,Parikh, V.,Evrard, E.,Ghosh, S.,Salafia, M.A.,Rago, B.,Obach, R.,Fonseca, K.R.,Chang, C.; Discovery of Hydroxamate Bioisosteres as KATII Inhibitors with Improved Oral Bioavailability and Pharmacokinetics; MEDCHEMCOMM, 2012; DOI: 10.1039/C2MD20166F

Experimental method

X-RAY DIFFRACTION (2.89 Å)