4GDY

Kynurenine Aminotransferase II inhibitors

4GDY の概要

• エントリーDOI: 10.2210/pdb4gdy/pdb
• 関連するPDBエントリー: 3UE8 4GE4 4GE7 4GE9 4GEB
• 分子名称: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (5-hydroxy-6-methyl-4-{[(1-oxo-7-phenoxy-1,2-dihydro[1,2,4]triazolo[4,3-a]quinolin-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate (3 entities in total)
• 機能のキーワード: aminotransferase, pyridoxal phosphate co-factor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion (Potential): Q8N5Z0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98947.02

構造登録者

Pandit, J. (登録日: 2012-08-01, 公開日: 2012-08-29, 最終更新日: 2023-09-13)

• 主引用文献: Verhoest, P.R.,Henderson, J.L.,Sawant-Basak, A.,Tuttle, J.B.,Dounay, A.B.,McAllister, L.A.,Pandit, J.,Rong, S.,Hou, X.,Bechle, B.,Parikh, V.,Evrard, E.,Ghosh, S.,Salafia, M.A.,Rago, B.,Obach, R.,Fonseca, K.R.,Chang, C.; Discovery of Hydroxamate Bioisosteres as KATII Inhibitors with Improved Oral Bioavailability and Pharmacokinetics; MEDCHEMCOMM, 2012; DOI: 10.1039/C2MD20166F

実験手法

X-RAY DIFFRACTION (2.89 Å)