4GB2

HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor

Summary for 4GB2

• Entry DOI: 10.2210/pdb4gb2/pdb
• Related: 3QIH 3QN8 3QP0
• Descriptor: Gag-Pol polyprotein, CHLORIDE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: dimer, aspartyl protease, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22387.76

Authors

Stieler, M.,Heine, A.,Klebe, G. (deposition date: 2012-07-26, release date: 2013-07-31, Last modification date: 2023-09-13)

• Primary citation: Stieler, M.,Klee, N.,Heine, A.,Doerr, S.,Diederich, W.,Klebe, G.; Cocrystallization of potent pyrrolidine based HIV-1 protease inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (1.788 Å)