4GB2
HIV-1 protease (mutant Q7K L33I L63I) in complex with a bicyclic pyrrolidine inhibitor
Summary for 4GB2
Entry DOI | 10.2210/pdb4gb2/pdb |
Related | 3QIH 3QN8 3QP0 |
Descriptor | Gag-Pol polyprotein, CHLORIDE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | dimer, aspartyl protease, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22387.76 |
Authors | Stieler, M.,Heine, A.,Klebe, G. (deposition date: 2012-07-26, release date: 2013-07-31, Last modification date: 2023-09-13) |
Primary citation | Stieler, M.,Klee, N.,Heine, A.,Doerr, S.,Diederich, W.,Klebe, G. Cocrystallization of potent pyrrolidine based HIV-1 protease inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (1.788 Å) |
Structure validation
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