4GAI
Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra
Summary for 4GAI
Entry DOI | 10.2210/pdb4gai/pdb |
Related | 4GAF |
Descriptor | EBI-005 (2 entities in total) |
Functional Keywords | il-1beta, il-1ra, il-1r1, il-1 signaling, beta-trefoil, signaling protein |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 35438.66 |
Authors | Hou, J.,Townson, S.A.,Kovalchin, J.T.,Masci, A.,Kiner, O.,Shu, Y.,King, B.,Thomas, C.,Garcia, K.C.,Furfine, E.S.,Barnes, T.M. (deposition date: 2012-07-25, release date: 2013-02-20, Last modification date: 2024-02-28) |
Primary citation | Hou, J.,Townson, S.A.,Kovalchin, J.T.,Masci, A.,Kiner, O.,Shu, Y.,King, B.M.,Schirmer, E.,Golden, K.,Thomas, C.,Garcia, K.C.,Zarbis-Papastoitsis, G.,Furfine, E.S.,Barnes, T.M. Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110:3913-3918, 2013 Cited by PubMed: 23431173DOI: 10.1073/pnas.1217996110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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