4GAH

Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor

Summary for 4GAH

Entry DOI	10.2210/pdb4gah/pdb
Descriptor	Thioesterase superfamily member 4, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-[(2R)-2-oxidanylundecyl]sulfanylethylamino]propyl]amino]butyl] hydrogen phosphate (3 entities in total)
Functional Keywords	hotdog fold, acyl coa hydrolase; akt c-terminal modulating protein, acyl-coa, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: Q5T1C6
Total number of polymer chains	2
Total formula weight	50738.99
Authors	Lim, K.,Pathak, M.C.,Herzberg, O. (deposition date: 2012-07-25, release date: 2012-08-29, Last modification date: 2023-09-13)
Primary citation	Zhao, H.,Lim, K.,Choudry, A.,Latham, J.A.,Pathak, M.C.,Dominguez, D.,Luo, L.,Herzberg, O.,Dunaway-Mariano, D. Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. Biochemistry, 51:6490-6492, 2012 Cited by PubMed: 22871024 DOI: 10.1021/bi300968n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation