4GAH
Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 0ET A 301 |
| Chain | Residue |
| A | LYS74 |
| A | HOH401 |
| A | HOH419 |
| A | HOH455 |
| B | PRO147 |
| B | HIS152 |
| B | GLY153 |
| B | ASN183 |
| B | TYR184 |
| B | LYS185 |
| B | ARG186 |
| A | ASP161 |
| B | PRO187 |
| A | MET176 |
| A | THR177 |
| A | ALA178 |
| A | ARG206 |
| A | LYS207 |
| A | LEU229 |
| A | ILE231 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE 0ET B 601 |
| Chain | Residue |
| A | GLY146 |
| A | PRO147 |
| A | HIS152 |
| A | GLY153 |
| A | ASN183 |
| A | TYR184 |
| A | LYS185 |
| A | ARG186 |
| A | PRO187 |
| B | MET176 |
| B | THR177 |
| B | ALA178 |
| B | ARG206 |
| B | LYS207 |
| B | LEU229 |
| B | ILE231 |
| B | LEU233 |
| B | HIS244 |
| B | HOH1012 |
| B | HOH1019 |
| B | HOH1024 |
| B | HOH1048 |
| B | HOH1061 |
| B | HOH1098 |
| B | HOH1112 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 0ET B 602 |
| Chain | Residue |
| B | TRP86 |
| B | MET169 |
| B | MET170 |
| B | GLY173 |
| B | GLU242 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22871024","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q3UUI3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UUI3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
