4G6K
Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state
Summary for 4G6K
Entry DOI | 10.2210/pdb4g6k/pdb |
Related | 4G5Z 4G6J 4G6M |
Descriptor | heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment (3 entities in total) |
Functional Keywords | immunoglobulin fold, immune system, cytokine, interleukine-1beta |
Biological source | homo Sapiens, Mus musculus (human, mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 46791.32 |
Authors | Blech, M.,Hoerer, S. (deposition date: 2012-07-19, release date: 2012-12-19, Last modification date: 2023-09-13) |
Primary citation | Blech, M.,Peter, D.,Fischer, P.,Bauer, M.M.,Hafner, M.,Zeeb, M.,Nar, H. One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425:94-111, 2013 Cited by PubMed: 23041424DOI: 10.1016/j.jmb.2012.09.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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