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4G6K

Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state

Experimental procedure
Experimental methodSINGLE WAVELENGTH
Source typeSYNCHROTRON
Source detailsSLS BEAMLINE X06SA
Synchrotron siteSLS
BeamlineX06SA
Temperature [K]100
Detector technologyPIXEL
Collection date2011-11-22
DetectorPSI PILATUS 6M
Wavelength(s)0.91
Spacegroup nameP 21 21 21
Unit cell lengths74.345, 75.092, 88.862
Unit cell angles90.00, 90.00, 90.00
Refinement procedure
Resolution27.750 - 1.900
R-factor0.184
Rwork0.183
R-free0.21080
Structure solution methodMOLECULAR REPLACEMENT
Starting model (for MR)1PZ5 and 3BKJ
RMSD bond length0.007
RMSD bond angle1.030
Data reduction softwareXDS
Data scaling softwareXDS
Phasing softwarePHASER
Refinement softwareBUSTER (2.11.2)
Data quality characteristics
 OverallOuter shell
Low resolution limit [Å]57.400
High resolution limit [Å]1.9001.900
Rmerge0.076
Number of reflections41364
<I/σ(I)>19.4
Completeness [%]100.0
Redundancy6.5
Crystallization Conditions
crystal IDmethodpHtemperaturedetails
1VAPOR DIFFUSION, SITTING DROP529314.3% w/v PEG 3350 and 0.14M tri-sodium citrate at pH 5.0 equilibrated against 24% w/v PEG 3350, VAPOR DIFFUSION, SITTING DROP, temperature 293K

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