4G5Y
Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in a ternary complex with ATP and N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE
Summary for 4G5Y
Entry DOI | 10.2210/pdb4g5y/pdb |
Related | 3COV 3COW 3COY 3COZ 4EF6 4EFK |
Descriptor | Pantothenate synthetase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | drug design, fragment-based, ligase, pantothenate biosynthesis, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 65147.60 |
Authors | Ciulli, A.,Silvestre, H.L.,Blundell, T.L.,Abell, C. (deposition date: 2012-07-18, release date: 2013-07-03, Last modification date: 2023-09-13) |
Primary citation | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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