4FXY
Crystal structure of rat neurolysin with bound pyrazolidin inhibitor
Summary for 4FXY
Entry DOI | 10.2210/pdb4fxy/pdb |
Related | 1I1I 2O3E |
Descriptor | Neurolysin, mitochondrial, 1-{(2S)-1-[(3R)-3-(2-chlorophenyl)-2-(2-fluorophenyl)pyrazolidin-1-yl]-1-oxopropan-2-yl}-3-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]urea, ZINC ION, ... (4 entities in total) |
Functional Keywords | hydrolase, endopeptidase, zinc metallopeptidase, neuropeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (rat) |
Total number of polymer chains | 2 |
Total formula weight | 159936.23 |
Authors | Rodgers, D.W.,Hines, C.S. (deposition date: 2012-07-03, release date: 2013-11-13, Last modification date: 2023-09-13) |
Primary citation | Hines, C.S.,Ray, K.,Schmidt, J.J.,Xiong, F.,Feenstra, R.W.,Pras-Raves, M.,de Moes, J.P.,Lange, J.H.,Melikishvili, M.,Fried, M.G.,Mortenson, P.,Charlton, M.,Patel, Y.,Courtney, S.M.,Kruse, C.G.,Rodgers, D.W. Allosteric inhibition of the neuropeptidase neurolysin. J.Biol.Chem., 289:35605-35619, 2014 Cited by PubMed: 25378390DOI: 10.1074/jbc.M114.620930 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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