4FXY
Crystal structure of rat neurolysin with bound pyrazolidin inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | P, Q | Neurolysin, mitochondrial | polymer | 693 | 79377.6 | 2 | UniProt (P42676) Pfam (PF01432) In PDB | Rattus norvegicus (rat) | Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase |
2 | P, Q | 1-{(2S)-1-[(3R)-3-(2-chlorophenyl)-2-(2-fluorophenyl)pyrazolidin-1-yl]-1-oxopropan-2-yl}-3-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]urea | non-polymer | 525.1 | 2 | Chemie (0W2) | |||
3 | P, Q | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
P, Q: 1 - 681 (UniProt: P42676)
PDB | External Database | Details |
---|---|---|
Asp -11 | - | expression tag |
Arg -10 | - | expression tag |
Trp -9 | - | expression tag |
Ile -8 | - | expression tag |
Arg -7 | - | expression tag |
Pro -6 | - | expression tag |
Arg -5 | - | expression tag |
Asp -4 | - | expression tag |
Leu -3 | - | expression tag |
Gln -2 | - | expression tag |
Met -1 | - | expression tag |
Val 0 | - | expression tag |
Ala 160 | His 183 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 158755.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1180.9 | |
All* | Total formula weight | 159936.2 |