4FQI

Crystal Structure of Fab CR9114 in Complex with a H5N1 influenza virus hemagglutinin

4FQI の概要

• エントリーDOI: 10.2210/pdb4fqi/pdb
• 関連するPDBエントリー: 4FNK 4FQH 4FQJ 4FQK 4FQL 4FQM 4FQV 4FQY
• 分子名称: Hemagglutinin HA1, Hemagglutinin HA2, antibody CR9114 heavy chain, ... (9 entities in total)
• 機能のキーワード: neutralizing antibodies, antibody affinity, antigens, epitopes, glycosylation, hemagglutinin glycoproteins, immunoglobulin fab fragments, h5n1 subtype, influenza vaccines, avian flu, envelope protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 107488.75

構造登録者

Dreyfus, C.,Wilson, I.A. (登録日: 2012-06-25, 公開日: 2012-08-22, 最終更新日: 2024-10-16)

主引用文献

Dreyfus, C.,Laursen, N.S.,Kwaks, T.,Zuijdgeest, D.,Khayat, R.,Ekiert, D.C.,Lee, J.H.,Metlagel, Z.,Bujny, M.V.,Jongeneelen, M.,van der Vlugt, R.,Lamrani, M.,Korse, H.J.,Geelen, E.,Sahin, O.,Sieuwerts, M.,Brakenhoff, J.P.,Vogels, R.,Li, O.T.,Poon, L.L.,Peiris, M.,Koudstaal, W.,Ward, A.B.,Wilson, I.A.,Goudsmit, J.,Friesen, R.H.
Highly conserved protective epitopes on influenza B viruses.
Science, 337:1343-1348, 2012

PubMed Abstract: Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.

PubMed: 22878502
DOI: 10.1126/science.1222908

実験手法

X-RAY DIFFRACTION (1.71 Å)