4FQI
Crystal Structure of Fab CR9114 in Complex with a H5N1 influenza virus hemagglutinin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hemagglutinin HA1 | polymer | 334 | 37948.0 | 1 | UniProt (Q6DQ33) Pfam (PF00509) | Influenza A virus | hemagglutinin receptor binding subunit HA1 |
| 2 | B (B) | Hemagglutinin HA2 | polymer | 177 | 20414.5 | 1 | UniProt (Q6DQ33) Pfam (PF00509) | Influenza A virus | hemagglutinin membrane fusion subunit HA2 |
| 3 | C (H) | antibody CR9114 heavy chain | polymer | 230 | 24423.2 | 1 | Homo sapiens (human) | ||
| 4 | D (L) | antibody CR9114 light chain | polymer | 216 | 22840.2 | 1 | Homo sapiens (human) | ||
| 5 | E (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F, G, H, I, K... (A, B, H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 7 | J, L, S (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 8 | M (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | U, V, W, X (A, B, H, L) | water | water | 18.0 | 1091 | Chemie (HOH) |
Sequence modifications
A: 11 - 333 (UniProt: Q6DQ33)
B: 1 - 174 (UniProt: Q6DQ33)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Gly 10 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 175 | - | expression tag |
| Gly 176 | - | expression tag |
| Arg 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 105625.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1438.5 | |
| All* | Total formula weight | 107488.8 |
