4FLI
Human MetAP1 with bengamide analog Y16, in Mn form
Summary for 4FLI
Entry DOI | 10.2210/pdb4fli/pdb |
Related | 3PKA 3PKB 3PKC 3PKD 3PKE 4FLJ 4FLK 4FLL |
Descriptor | Methionine aminopeptidase 1, MANGANESE (II) ION, (E,2R,3R,4S,5R)-N-(2-azanyl-2-oxidanylidene-ethyl)-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, ... (5 entities in total) |
Functional Keywords | enzyme-inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P53582 |
Total number of polymer chains | 1 |
Total formula weight | 37296.12 |
Authors | |
Primary citation | Xu, W.,Lu, J.P.,Ye, Q.Z. Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J.Med.Chem., 55:8021-8027, 2012 Cited by PubMed: 22913487DOI: 10.1021/jm3008695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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