4FGU

Crystal structure of prolegumain

4FGU の概要

• エントリーDOI: 10.2210/pdb4fgu/pdb
• 関連するPDBエントリー: 4aw9 4awa 4awb
• 分子名称: Legumain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: cysteine protease, aep, asparaginyl endopeptidase, substrate specificity, mhcii, antigen processing, proenzyme, cancer, lysosomal, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99702.16

構造登録者

Dall, E.,Brandstetter, H. (登録日: 2012-06-05, 公開日: 2013-07-03, 最終更新日: 2020-07-29)

• 主引用文献: Dall, E.,Brandstetter, H.; Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.; Proc.Natl.Acad.Sci.USA, 110:10940-10945, 2013; PubMed: 23776206; DOI: 10.1073/pnas.1300686110

実験手法

X-RAY DIFFRACTION (3.9 Å)