4AW9
Crystal structure of active legumain in complex with YVAD-CMK
Summary for 4AW9
Entry DOI | 10.2210/pdb4aw9/pdb |
Related | 4AWA 4AWB 4FGU |
Related PRD ID | PRD_002086 |
Descriptor | LEGUMAIN, ACE-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, cysteine protease, lysosomal, aep, substrate specificity, mhcii, antigen processing, cancer, hydrolase/hydrolase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 33750.01 |
Authors | Dall, E.,Brandstetter, H. (deposition date: 2012-06-01, release date: 2013-06-26, Last modification date: 2020-07-29) |
Primary citation | Dall, E.,Brandstetter, H. Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation Proc.Natl.Acad.Sci.USA, 110:10940-, 2013 Cited by PubMed: 23776206DOI: 10.1073/PNAS.1300686110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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