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4FDC

Crystal structure of the E493V mutant of human apoptosis inducing factor (AIF)

Summary for 4FDC
Entry DOI10.2210/pdb4fdc/pdb
Related1M6I
DescriptorApoptosis-inducing factor 1, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE (2 entities in total)
Functional Keywordsrossmann fold, mitochondrion, appoptosis, oxidoreductase, apoptosis
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion intermembrane space: O95831
Total number of polymer chains1
Total formula weight56837.26
Authors
Sevrioukova, I.F. (deposition date: 2012-05-27, release date: 2012-10-17, Last modification date: 2023-09-13)
Primary citationRinaldi, C.,Grunseich, C.,Sevrioukova, I.F.,Schindler, A.,Horkayne-Szakaly, I.,Lamperti, C.,Landoure, G.,Kennerson, M.L.,Burnett, B.G.,Bonnemann, C.,Biesecker, L.G.,Ghezzi, D.,Zeviani, M.,Fischbeck, K.H.
Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
Am.J.Hum.Genet., 91:1095-1102, 2012
Cited by
PubMed: 23217327
DOI: 10.1016/j.ajhg.2012.10.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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