4FDC

Crystal structure of the E493V mutant of human apoptosis inducing factor (AIF)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0016491	molecular_function	oxidoreductase activity
B	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FAD B 1000

Chain	Residue
B	GLY138
B	SER176
B	LYS177
B	LYS232
B	VAL233
B	ALA259
B	THR260
B	GLY261
B	ARG285
B	LEU311
B	GLY437
B	GLY139
B	ASP438
B	GLU453
B	HIS454
B	HIS455
B	PHE482
B	TRP483
B	GLY140
B	THR141
B	ALA142
B	VAL162
B	GLU164
B	ARG172
B	PRO173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	349
Details	Region: {"description":"FAD-dependent oxidoreductase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22103349","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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