4F9U

Structure of glycosylated glutaminyl cyclase from Drosophila melanogaster

4F9U の概要

• エントリーDOI: 10.2210/pdb4f9u/pdb
• 関連するPDBエントリー: 3SI2 4F9V 4FAI 4FBE
• 分子名称: CG32412, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: alpha/beta hydrolase, pglu formation, pe, alzheimer's disease, pyroglutamate, pglu-amyloid, glycosylation, transferase, hydrolase
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73206.58

構造登録者

Kolenko, P.,Koch, B.,Ruiz-Carilo, D.,Stubbs, M.T. (登録日: 2012-05-21, 公開日: 2012-08-29, 最終更新日: 2023-09-13)

• 主引用文献: Koch, B.,Kolenko, P.,Buchholz, M.,Ruiz Carrillo, D.,Parthier, C.,Wermann, M.,Rahfeld, J.U.,Reuter, G.,Schilling, S.,Stubbs, M.T.,Demuth, H.U.; Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.; Biochemistry, 51:7383-7392, 2012; PubMed: 22897232; DOI: 10.1021/bi300687g

実験手法

X-RAY DIFFRACTION (1.8 Å)