4F9B

Human CDC7 kinase in complex with DBF4 and PHA767491

Summary for 4F9B

• Entry DOI: 10.2210/pdb4f9b/pdb
• Related: 4F99 4F9A 4F9C
• Descriptor: Cell division cycle 7-related protein kinase, Protein DBF4 homolog A, 2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one, ... (5 entities in total)
• Functional Keywords: ser/thr protein kinase, transferase, phosphorylation, cell cycle, cell division, mitosis, s phase, serine/threonine-protein kinase, dbf4-dependent kinase, ddk, atp-binding, nucleotide-binding, zinc-binding, nucleus, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O00311 Q9UBU7
• Total number of polymer chains: 4
• Total formula weight: 115671.77

Authors

Hughes, S.,Cherepanov, P. (deposition date: 2012-05-18, release date: 2012-10-31, Last modification date: 2024-02-28)

• Primary citation: Hughes, S.,Elustondo, F.,Di Fonzo, A.,Leroux, F.G.,Wong, A.C.,Snijders, A.P.,Matthews, S.J.,Cherepanov, P.; Crystal structure of human CDC7 kinase in complex with its activator DBF4.; Nat.Struct.Mol.Biol., 19:1101-1107, 2012; PubMed: 23064647; DOI: 10.1038/nsmb.2404

Experimental method

X-RAY DIFFRACTION (2.5 Å)