4F9B

Human CDC7 kinase in complex with DBF4 and PHA767491

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cell division cycle 7-related protein kinase	polymer	361	40633.8	2	UniProt (O00311) Pfam (PF00069)	Homo sapiens (human)	CDC7-related kinase, HsCdc7, huCdc7
2	B, D (B, D)	Protein DBF4 homolog A	polymer	144	16923.4	2	UniProt (Q9UBU7) Pfam (PF07535)	Homo sapiens (human)	Activator of S phase kinase, Chiffon homolog A, DBF4-type zinc finger-containing protein 1
3	E, G (A, C)	2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one	non-polymer		213.2	2	Chemie (0SY)
4	F, H (B, D)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	I, J, K, L (A, B, C, D)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A, C: 37 - 359 (UniProt: O00311)

PDB	External Database	Details
Met 36	-	expression tag

A, C: 360 - 529 (UniProt: O00311)
A, C: 530 - 574 (UniProt: O00311)
B, D: 210 - 350 (UniProt: Q9UBU7)

PDB	External Database	Details
Gly 207	-	expression tag
Pro 208	-	expression tag
Gly 209	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	115114.5
Non-Polymers*	Number of molecules	4
	Total formula weight	557.3
All*	Total formula weight	115671.8

*Water molecules are not included.