4F5D

ERIS/STING in complex with ligand

Summary for 4F5D

• Entry DOI: 10.2210/pdb4f5d/pdb
• Related: 4F5E
• Descriptor: Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: receptor, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Multi-pass membrane protein : Q86WV6
• Total number of polymer chains: 2
• Total formula weight: 57985.77

Authors

Huang, Y.H.,Liu, X.Y.,Su, X.D. (deposition date: 2012-05-13, release date: 2012-06-27, Last modification date: 2024-03-20)

Primary citation

Huang, Y.H.,Liu, X.Y.,Du, X.X.,Jiang, Z.F.,Su, X.D.
The structural basis for the sensing and binding of cyclic di-GMP by STING
Nat.Struct.Mol.Biol., 19:728-730, 2012

PubMed Abstract: STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function.

PubMed: 22728659
DOI: 10.1038/nsmb.2333

Experimental method

X-RAY DIFFRACTION (3 Å)