4F5D
ERIS/STING in complex with ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE C2E A 401 |
| Chain | Residue |
| A | TYR167 |
| A | HOH501 |
| B | TYR167 |
| B | ILE235 |
| B | ARG238 |
| B | VAL239 |
| B | TYR240 |
| B | SER241 |
| B | GLU260 |
| B | THR263 |
| B | MG401 |
| A | ILE235 |
| B | HOH501 |
| A | ARG238 |
| A | VAL239 |
| A | TYR240 |
| A | SER241 |
| A | GLU260 |
| A | THR263 |
| A | MG402 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | GLY166 |
| A | ARG232 |
| A | ARG238 |
| A | TYR240 |
| A | C2E401 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| A | C2E401 |
| B | GLY166 |
| B | ARG232 |
| B | ARG238 |
| B | TYR240 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 374 |
| Details | Region: {"description":"Cyclic dinucleotide-binding domain (CBD)","evidences":[{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37379839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GJX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31968013","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q3TBT3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
