4F5D

ERIS/STING in complex with ligand

Summary for 4F5D

• Entry DOI: 10.2210/pdb4f5d/pdb
• Related: 4F5E
• Descriptor: Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: receptor, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Multi-pass membrane protein : Q86WV6
• Total number of polymer chains: 2
• Total formula weight: 57985.77

Authors

Huang, Y.H.,Liu, X.Y.,Su, X.D. (deposition date: 2012-05-13, release date: 2012-06-27, Last modification date: 2024-03-20)

• Primary citation: Huang, Y.H.,Liu, X.Y.,Du, X.X.,Jiang, Z.F.,Su, X.D.; The structural basis for the sensing and binding of cyclic di-GMP by STING; Nat.Struct.Mol.Biol., 19:728-730, 2012; PubMed: 22728659; DOI: 10.1038/nsmb.2333

Experimental method

X-RAY DIFFRACTION (3 Å)