4F5D

ERIS/STING in complex with ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transmembrane protein 173	polymer	256	28623.4	2	UniProt (Q86WV6) Pfam (PF15009)	Homo sapiens (human)	Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING
2	C (A)	9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)	non-polymer		690.4	1	Chemie (C2E) PubChem (135440063) PubChem (135566344) PubChem (136437725) PubChem (136465801) PubChem (136503951) PubChem (146177770) PubChem (135566464) PubChem (135625254) PubChem (135867623) PubChem (135975628) PubChem (136177399) PubChem (136443483) PubChem (137221491) PubChem (137295286) PubChem (148921766) PubChem (148921769) PubChem (173716374) PubChem (174009991) PubChem (164708340) PubChem (168270823)
3	D, E (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG) PubChem (888)
4	F, G (A, B)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 141 - 379 (UniProt: Q86WV6)

PDB	External Database	Details
Gly 124	-	expression tag
Ser 125	-	expression tag
His 126	-	expression tag
Met 127	-	expression tag
Ala 128	-	expression tag
Ser 129	-	expression tag
Met 130	-	expression tag
Thr 131	-	expression tag
Gly 132	-	expression tag
Gly 133	-	expression tag
Met 134	-	expression tag
Gly 135	-	expression tag
Arg 136	-	expression tag
Gly 137	-	expression tag
Ser 138	-	expression tag
Met 139	-	expression tag
Met 140	-	expression tag
Ala 230	Gly 230	engineered mutation
Arg 232	His 232	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57246.8
Non-Polymers*	Number of molecules	3
	Total formula weight	739.0
All*	Total formula weight	57985.8

*Water molecules are not included.