4F5D

ERIS/STING in complex with ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transmembrane protein 173	polymer	256	28623.4	2	UniProt (Q86WV6) Pfam (PF15009)	Homo sapiens (human)	Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING
2	C (A)	9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)	non-polymer		690.4	1	Chemie (C2E)
3	D, E (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	F, G (A, B)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 141 - 379 (UniProt: Q86WV6)

PDB	External Database	Details
Gly 124	-	expression tag
Ser 125	-	expression tag
His 126	-	expression tag
Met 127	-	expression tag
Ala 128	-	expression tag
Ser 129	-	expression tag
Met 130	-	expression tag
Thr 131	-	expression tag
Gly 132	-	expression tag
Gly 133	-	expression tag
Met 134	-	expression tag
Gly 135	-	expression tag
Arg 136	-	expression tag
Gly 137	-	expression tag
Ser 138	-	expression tag
Met 139	-	expression tag
Met 140	-	expression tag
Ala 230	Gly 230	engineered mutation
Arg 232	His 232	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57246.8
Non-Polymers*	Number of molecules	3
	Total formula weight	739.0
All*	Total formula weight	57985.8

*Water molecules are not included.