4F49

2.25A resolution structure of Transmissible Gastroenteritis Virus Protease containing a covalently bound Dipeptidyl Inhibitor

Summary for 4F49

Entry DOI	10.2210/pdb4f49/pdb
Descriptor	3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, TETRAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	protease, antiviral inhibitors, dipeptidyl inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Porcine transmissible gastroenteritis coronavirus (TGEV)
Total number of polymer chains	4
Total formula weight	138754.62
Authors	Lovell, S.,Battaile, K.P.,Kim, Y.,Tiew, K.-C.,Mandadapu, S.R.,Alliston, K.R.,Groutas, W.C.,Chang, K.-O. (deposition date: 2012-05-10, release date: 2012-09-05, Last modification date: 2023-09-13)
Primary citation	Kim, Y.,Lovell, S.,Tiew, K.C.,Mandadapu, S.R.,Alliston, K.R.,Battaile, K.P.,Groutas, W.C.,Chang, K.O. Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses. J.Virol., 86:11754-11762, 2012 Cited by PubMed: 22915796 DOI: 10.1128/JVI.01348-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation