4F49
2.25A resolution structure of Transmissible Gastroenteritis Virus Protease containing a covalently bound Dipeptidyl Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3C-like proteinase | polymer | 310 | 34154.5 | 4 | UniProt (P0C6V2) Pfam (PF05409) | Porcine transmissible gastroenteritis coronavirus (TGEV) | 3CL-PRO, 3CLp, M-PRO, nsp5, p34 |
| 2 | E, F, G, H (A, B, C, D) | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | non-polymer | 485.6 | 4 | Chemie (K36) PubChem (77987125) PubChem (71481120) PubChem (131704476) PubChem (118737648) PubChem (131704478) PubChem (137348969) PubChem (137349627) PubChem (138734767) PubChem (156198974) PubChem (172472623) PubChem (162651992) PubChem (163337713) PubChem (169544973) | |||
| 3 | I (D) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) PubChem (8200) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 303 (UniProt: P0C6V2)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 136618.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2136.4 | |
| All* | Total formula weight | 138754.6 |
