4F2C

The Crystal Structure of a Human MitoNEET double mutant in which Gly 66 are Asp 67 are both Replaced with Ala Residues

Summary for 4F2C

• Entry DOI: 10.2210/pdb4f2c/pdb
• Related: 2QH7 3EW0 3LPQ 4EZF 4F1E 4F28
• Descriptor: CDGSH iron-sulfur domain-containing protein 1, FE2/S2 (INORGANIC) CLUSTER (3 entities in total)
• Functional Keywords: mitochondrial outer membrane, signal-anchor, transmembrane metal binding protein, protein frustration, metal binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion outer membrane; Single-pass type III membrane protein: Q9NZ45
• Total number of polymer chains: 2
• Total formula weight: 18188.33

Authors

Baxter, E.L.,Zuris, J.A.,Wang, C.,Axelrod, H.L.,Cohen, A.E.,Paddock, M.L.,Nechushtai, R.,Onuchic, J.N.,Jennings, P.A. (deposition date: 2012-05-07, release date: 2012-12-26, Last modification date: 2023-09-13)

• Primary citation: Baxter, E.L.,Zuris, J.A.,Wang, C.,Vo, P.L.,Axelrod, H.L.,Cohen, A.E.,Paddock, M.L.,Nechushtai, R.,Onuchic, J.N.,Jennings, P.A.; Allosteric control in a metalloprotein dramatically alters function.; Proc.Natl.Acad.Sci.USA, 110:948-953, 2013; PubMed: 23271805; DOI: 10.1073/pnas.1208286110

Experimental method

X-RAY DIFFRACTION (1.35 Å)