4EZ8
Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate
Summary for 4EZ8
Entry DOI | 10.2210/pdb4ez8/pdb |
Related | 4EIN |
Descriptor | Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), DIHYDROFOLIC ACID, ... (5 entities in total) |
Functional Keywords | methyltransferase, ternary complex, dihydrofolic acid, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Nucleus (By similarity): P07607 |
Total number of polymer chains | 1 |
Total formula weight | 35951.81 |
Authors | Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Wilk, P.,Kierdaszuk, B.,Banaszak, K.,Gorecka, K.,Rode, W. (deposition date: 2012-05-02, release date: 2013-05-08, Last modification date: 2024-02-28) |
Primary citation | Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Wilk, P.,Kierdaszuk, B.,Banaszak, K.,Gorecka, K.,Rode, W. Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate Pteridines, 2013 |
Experimental method | X-RAY DIFFRACTION (1.17 Å) |
Structure validation
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