4EIN

Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate

Summary for 4EIN

• Entry DOI: 10.2210/pdb4ein/pdb
• Descriptor: Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), GLYCEROL, ... (4 entities in total)
• Functional Keywords: methyltransferase, binding site, catalysis, dimerization, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Nucleus (By similarity): P07607
• Total number of polymer chains: 2
• Total formula weight: 70740.52

Authors

Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Kierdaszuk, B.,Rode, W. (deposition date: 2012-04-05, release date: 2013-04-10, Last modification date: 2023-09-13)

• Primary citation: Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Kierdaszuk, B.,Rode, W.; Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate; PTERIDINES, 2013

Experimental method

X-RAY DIFFRACTION (1.75 Å)