4EIN
Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate
Summary for 4EIN
Entry DOI | 10.2210/pdb4ein/pdb |
Descriptor | Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), GLYCEROL, ... (4 entities in total) |
Functional Keywords | methyltransferase, binding site, catalysis, dimerization, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Nucleus (By similarity): P07607 |
Total number of polymer chains | 2 |
Total formula weight | 70740.52 |
Authors | Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Kierdaszuk, B.,Rode, W. (deposition date: 2012-04-05, release date: 2013-04-10, Last modification date: 2023-09-13) |
Primary citation | Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Kierdaszuk, B.,Rode, W. Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate PTERIDINES, 2013 |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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