4EZ8

Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate

4EZ8 の概要

• エントリーDOI: 10.2210/pdb4ez8/pdb
• 関連するPDBエントリー: 4EIN
• 分子名称: Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), DIHYDROFOLIC ACID, ... (5 entities in total)
• 機能のキーワード: methyltransferase, ternary complex, dihydrofolic acid, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Nucleus (By similarity): P07607
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35951.81

構造登録者

Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Wilk, P.,Kierdaszuk, B.,Banaszak, K.,Gorecka, K.,Rode, W. (登録日: 2012-05-02, 公開日: 2013-05-08, 最終更新日: 2024-02-28)

• 主引用文献: Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Wilk, P.,Kierdaszuk, B.,Banaszak, K.,Gorecka, K.,Rode, W.; Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate; Pteridines, 2013

実験手法

X-RAY DIFFRACTION (1.17 Å)