4EYL

Crystal structure of NDM-1 bound to hydrolyzed meropenem

Summary for 4EYL

Entry DOI	10.2210/pdb4eyl/pdb
Related	3Q6X 3SPU 4EXY 4EY2 4EYB 4EYF 4EYL
Descriptor	Beta-lactamase NDM-1, (2S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-2H-pyrro le-5-carboxylic acid, ZINC ION, ... (4 entities in total)
Functional Keywords	metallo-beta-lactamase, antibiotic, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Klebsiella pneumoniae
Cellular location	Periplasm : C7C422
Total number of polymer chains	2
Total formula weight	58539.99
Authors	Strynadka, N.C.J.,King, D.T. (deposition date: 2012-05-01, release date: 2012-08-08, Last modification date: 2024-02-28)
Primary citation	King, D.T.,Worrall, L.J.,Gruninger, R.,Strynadka, N.C. New Delhi Metallo-Beta-Lactamase: Structural Insights into Beta-Lactam Recognition and Inhibition J.Am.Chem.Soc., 134:11362-11365, 2012 Cited by PubMed: 22713171 DOI: 10.1021/ja303579d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation