4EK9
Crystal structure of DOT1L in complex with EPZ000004
Summary for 4EK9
Entry DOI | 10.2210/pdb4ek9/pdb |
Related | 3QOW 4EKG 4EKI |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-79 specific, 5'-deoxy-5'-(dimethylamino)adenosine, SULFATE ION, ... (5 entities in total) |
Functional Keywords | methyltransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Probable): Q8TEK3 |
Total number of polymer chains | 1 |
Total formula weight | 49144.76 |
Authors | |
Primary citation | Basavapathruni, A.,Jin, L.,Daigle, S.R.,Majer, C.R.,Therkelsen, C.A.,Wigle, T.J.,Kuntz, K.W.,Chesworth, R.,Pollock, R.M.,Scott, M.P.,Moyer, M.P.,Richon, V.M.,Copeland, R.A.,Olhava, E.J. Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des., 80:971-980, 2012 Cited by PubMed: 22978415DOI: 10.1111/cbdd.12050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report