4EK9

Crystal structure of DOT1L in complex with EPZ000004

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone-lysine N-methyltransferase, H3 lysine-79 specific	polymer	425	48566.2	1	UniProt (Q8TEK3) Pfam (PF08123) In PDB	Homo sapiens (human)	DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4
2	A	5'-deoxy-5'-(dimethylamino)adenosine	non-polymer		294.3	1	Chemie (EP4)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	42	Chemie (HOH)

Sequence modifications

A: 1 - 416 (UniProt: Q8TEK3)

PDB	External Database	Details
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	48566.2
Non-Polymers*	Number of molecules	4
	Total formula weight	578.5
All*	Total formula weight	49144.8

*Water molecules are not included.