4EK9
Crystal structure of DOT1L in complex with EPZ000004
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE EP4 A 501 |
| Chain | Residue |
| A | PRO133 |
| A | PHE223 |
| A | ASN241 |
| A | HOH641 |
| A | GLU134 |
| A | VAL135 |
| A | GLY137 |
| A | GLY163 |
| A | GLU186 |
| A | LYS187 |
| A | GLY221 |
| A | ASP222 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | SER140 |
| A | PHE141 |
| A | ASP142 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | THR104 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | VAL160 |
| A | TYR183 |
| A | ARG231 |
| A | ASN234 |
| A | THR235 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | PHE159 | |
| A | GLU186 | |
| A | ASP222 | |
| A | TYR136 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER297 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER374 |
