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4EK9

Crystal structure of DOT1L in complex with EPZ000004

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE EP4 A 501
ChainResidue
APRO133
APHE223
AASN241
AHOH641
AGLU134
AVAL135
AGLY137
AGLY163
AGLU186
ALYS187
AGLY221
AASP222

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 502
ChainResidue
ASER140
APHE141
AASP142

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SO4 A 503
ChainResidue
ATHR104

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 504
ChainResidue
AVAL160
ATYR183
AARG231
AASN234
ATHR235

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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