4EK9

Crystal structure of DOT1L in complex with EPZ000004

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0031151	molecular_function	histone H3K79 methyltransferase activity
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EP4 A 501

Chain	Residue
A	PRO133
A	PHE223
A	ASN241
A	HOH641
A	GLU134
A	VAL135
A	GLY137
A	GLY163
A	GLU186
A	LYS187
A	GLY221
A	ASP222

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	SER140
A	PHE141
A	ASP142

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	THR104

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 504

Chain	Residue
A	VAL160
A	TYR183
A	ARG231
A	ASN234
A	THR235

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00902","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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