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4EA4

Structure of the glycosylase domain of MBD4 bound to 5hmU-containing DNA

Summary for 4EA4
Entry DOI10.2210/pdb4ea4/pdb
Related4E9E 4E9F 4E9G 4E9H 4EAB
DescriptorMethyl-CpG-binding domain protein 4, DNA (5'-D(*CP*CP*AP*GP*CP*GP*(5HU)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), ... (4 entities in total)
Functional Keywordshhh dna glycosylase family, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: O95243
Total number of polymer chains3
Total formula weight26073.39
Authors
Morera, S.,Vigouroux, A. (deposition date: 2012-03-22, release date: 2012-08-08, Last modification date: 2023-09-13)
Primary citationMorera, S.,Grin, I.,Vigouroux, A.,Couve, S.,Henriot, V.,Saparbaev, M.,Ishchenko, A.A.
Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
Nucleic Acids Res., 40:9917-9926, 2012
Cited by
PubMed: 22848106
DOI: 10.1093/nar/gks714
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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