4EA4
Structure of the glycosylase domain of MBD4 bound to 5hmU-containing DNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Methyl-CpG-binding domain protein 4 | polymer | 155 | 18713.6 | 1 | UniProt (O95243) In PDB | Homo sapiens (human) | Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase |
2 | C | DNA (5'-D(*CP*CP*AP*GP*CP*GP*(5HU)P*GP*CP*AP*GP*C)-3') | polymer | 12 | 3664.4 | 1 | |||
3 | D | DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3') | polymer | 12 | 3695.4 | 1 | |||
4 | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 427 - 574 (UniProt: O95243)
PDB | External Database | Details |
---|---|---|
Met 426 | - | expression tag |
Ala 560 | Asp 560 | engineered mutation |
His 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
His 578 | - | expression tag |
His 579 | - | expression tag |
His 580 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 26073.4 | |
All* | Total formula weight | 26073.4 |