4E7I

PFV intasome freeze-trapped prior to 3'-processing, Mn-bound form (UI-Mn)

Summary for 4E7I

• Entry DOI: 10.2210/pdb4e7i/pdb
• Related: 3DLR 3OY9 3OYA
• Descriptor: Pro-Pol polyprotein, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*AP*AP*T)-3'), ... (10 entities in total)
• Functional Keywords: protein-dna complex, tetramer, hhcc motif, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, virion, dna-binding, zinc-binding, viral protein, recombination, viral protein-dna complex, recombination-dna complex, recombination/dna
• Biological source: Human spumaretrovirus (SFVcpz(hu)); More
• Cellular location: Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350
• Total number of polymer chains: 4
• Total formula weight: 102317.71

Authors

Hare, S.,Cherepanov, P. (deposition date: 2012-03-17, release date: 2012-05-23, Last modification date: 2024-02-28)

• Primary citation: Hare, S.,Maertens, G.N.,Cherepanov, P.; 3'-Processing and strand transfer catalysed by retroviral integrase in crystallo.; Embo J., 31:3020-3028, 2012; PubMed: 22580823; DOI: 10.1038/emboj.2012.118

Experimental method

X-RAY DIFFRACTION (2.5301 Å)