4DVI

Crystal structure of Tankyrase 1 with IWR2

Summary for 4DVI

• Entry DOI: 10.2210/pdb4dvi/pdb
• Related: 2RF5
• Descriptor: Tankyrase-1, ZINC ION, 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(4-methylquinolin-8-yl)benzamide, ... (4 entities in total)
• Functional Keywords: tankyrase, parp, inhibitor, iwr2, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O95271
• Total number of polymer chains: 2
• Total formula weight: 51060.41

Authors

Huang, X. (deposition date: 2012-02-23, release date: 2012-04-04, Last modification date: 2024-02-28)

Primary citation

Gunaydin, H.,Gu, Y.,Huang, X.
Novel binding mode of a potent and selective tankyrase inhibitor.
Plos One, 7:e33740-e33740, 2012

PubMed Abstract: Tankyrases (TNKS1 and TNKS2) are key regulators of cellular processes such as telomere pathway and Wnt signaling. IWRs (inhibitors of Wnt response) have recently been identified as potent and selective inhibitors of tankyrases. However, it is not clear how these IWRs interact with tankyrases. Here we report the crystal structure of the catalytic domain of human TNKS1 in complex with IWR2, which reveals a novel binding site for tankyrase inhibitors. The TNKS1/IWR2 complex provides a molecular basis for their strong and specific interactions and suggests clues for further development of tankyrase inhibitors.

PubMed: 22438990
DOI: 10.1371/journal.pone.0033740

Experimental method

X-RAY DIFFRACTION (1.9 Å)