4DVI

Crystal structure of Tankyrase 1 with IWR2

4DVI の概要

• エントリーDOI: 10.2210/pdb4dvi/pdb
• 関連するPDBエントリー: 2RF5
• 分子名称: Tankyrase-1, ZINC ION, 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(4-methylquinolin-8-yl)benzamide, ... (4 entities in total)
• 機能のキーワード: tankyrase, parp, inhibitor, iwr2, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: O95271
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51060.41

構造登録者

Huang, X. (登録日: 2012-02-23, 公開日: 2012-04-04, 最終更新日: 2024-02-28)

主引用文献

Gunaydin, H.,Gu, Y.,Huang, X.
Novel binding mode of a potent and selective tankyrase inhibitor.
Plos One, 7:e33740-e33740, 2012

PubMed Abstract: Tankyrases (TNKS1 and TNKS2) are key regulators of cellular processes such as telomere pathway and Wnt signaling. IWRs (inhibitors of Wnt response) have recently been identified as potent and selective inhibitors of tankyrases. However, it is not clear how these IWRs interact with tankyrases. Here we report the crystal structure of the catalytic domain of human TNKS1 in complex with IWR2, which reveals a novel binding site for tankyrase inhibitors. The TNKS1/IWR2 complex provides a molecular basis for their strong and specific interactions and suggests clues for further development of tankyrase inhibitors.

PubMed: 22438990
DOI: 10.1371/journal.pone.0033740

実験手法

X-RAY DIFFRACTION (1.9 Å)