4DN4

Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a

Summary for 4DN4

• Entry DOI: 10.2210/pdb4dn4/pdb
• Related: 4DN3
• Descriptor: CNTO888 LIGHT CHAIN, CNTO888 HEAVY CHAIN, C-C motif chemokine 2, ... (6 entities in total)
• Functional Keywords: antibody chemokine, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted : P13500
• Total number of polymer chains: 3
• Total formula weight: 56742.44

Authors

Obmolova, G.,Teplyakov, A.,Malia, T.,Grygiel, T.,Sweet, R.,Snyder, L.,Gilliland, G. (deposition date: 2012-02-08, release date: 2012-10-03, Last modification date: 2018-01-24)

• Primary citation: Obmolova, G.,Teplyakov, A.,Malia, T.J.,Grygiel, T.L.,Sweet, R.,Snyder, L.A.,Gilliland, G.L.; Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888.; Mol.Immunol., 51:227-233, 2012; PubMed: 22487721; DOI: 10.1016/j.molimm.2012.03.022

Experimental method

X-RAY DIFFRACTION (2.8 Å)