4DN4
Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | CNTO888 LIGHT CHAIN | polymer | 216 | 23625.2 | 1 | Homo sapiens (human) | ||
| 2 | B (H) | CNTO888 HEAVY CHAIN | polymer | 228 | 24175.0 | 1 | Homo sapiens (human) | ||
| 3 | C (M) | C-C motif chemokine 2 | polymer | 76 | 8673.0 | 1 | UniProt (P13500) Pfam (PF00048) | HOMO SAPIENS | HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2 |
| 4 | D, E, F (L, H) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | G (H) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | H, I, J (L, H, M) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
M: 1 - 76 (UniProt: P13500)
| PDB | External Database | Details |
|---|---|---|
| Ala 8 | Pro 31 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 56473.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 269.2 | |
| All* | Total formula weight | 56742.4 |
