Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4DN4

Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0001525	biological_process	angiogenesis
M	0002548	biological_process	monocyte chemotaxis
M	0004672	molecular_function	protein kinase activity
M	0005102	molecular_function	signaling receptor binding
M	0005125	molecular_function	cytokine activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0006468	biological_process	protein phosphorylation
M	0006935	biological_process	chemotaxis
M	0006954	biological_process	inflammatory response
M	0006955	biological_process	immune response
M	0006959	biological_process	humoral immune response
M	0007010	biological_process	cytoskeleton organization
M	0007155	biological_process	cell adhesion
M	0007165	biological_process	signal transduction
M	0007166	biological_process	cell surface receptor signaling pathway
M	0007186	biological_process	G protein-coupled receptor signaling pathway
M	0007187	biological_process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
M	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
M	0008009	molecular_function	chemokine activity
M	0008360	biological_process	regulation of cell shape
M	0009617	biological_process	response to bacterium
M	0009887	biological_process	animal organ morphogenesis
M	0010628	biological_process	positive regulation of gene expression
M	0010759	biological_process	positive regulation of macrophage chemotaxis
M	0019079	biological_process	viral genome replication
M	0019221	biological_process	cytokine-mediated signaling pathway
M	0019233	biological_process	sensory perception of pain
M	0019725	biological_process	cellular homeostasis
M	0030335	biological_process	positive regulation of cell migration
M	0031727	molecular_function	CCR2 chemokine receptor binding
M	0034351	biological_process	negative regulation of glial cell apoptotic process
M	0035684	biological_process	helper T cell extravasation
M	0038148	biological_process	chemokine (C-C motif) ligand 2 signaling pathway
M	0042056	molecular_function	chemoattractant activity
M	0043524	biological_process	negative regulation of neuron apoptotic process
M	0043615	biological_process	astrocyte cell migration
M	0044344	biological_process	cellular response to fibroblast growth factor stimulus
M	0048020	molecular_function	CCR chemokine receptor binding
M	0048245	biological_process	eosinophil chemotaxis
M	0048246	biological_process	macrophage chemotaxis
M	0050870	biological_process	positive regulation of T cell activation
M	0050918	biological_process	positive chemotaxis
M	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
M	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
M	0070098	biological_process	chemokine-mediated signaling pathway
M	0071222	biological_process	cellular response to lipopolysaccharide
M	0071346	biological_process	cellular response to type II interferon
M	0071347	biological_process	cellular response to interleukin-1
M	0071356	biological_process	cellular response to tumor necrosis factor
M	0090280	biological_process	positive regulation of calcium ion import
M	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
M	1905563	biological_process	negative regulation of vascular endothelial cell proliferation
M	2000134	biological_process	negative regulation of G1/S transition of mitotic cell cycle
M	2000353	biological_process	positive regulation of endothelial cell apoptotic process
M	2000427	biological_process	positive regulation of apoptotic cell clearance
M	2000502	biological_process	negative regulation of natural killer cell chemotaxis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT L 1001

Chain	Residue
H	SER118
H	SER119
H	ASP150
L	SER129
L	THR131

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT H 301

Chain	Residue
H	GLN111

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT H 302

Chain	Residue
H	LYS215
H	LYS216

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL H 303

Chain	Residue
H	PRO155
H	VAL156
H	PRO173
H	ALA174
H	GLU154

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR194-HIS200
H	TYR200-HIS206

site_id	PS00472
Number of Residues	43
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCYnftnrk..IsvqrLasYrritssk.Cpke.AVIFktivakei.CA

Chain	Residue	Details
M	CYS11-ALA53

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Involved in dimerization

Chain	Residue	Details
M	ALA8
M	LYS35
M	LYS38

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Involved in dimerization, receptor binding and signaling

Chain	Residue	Details
M	TYR13

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Involved in GAG binding

Chain	Residue	Details
M	ARG18
M	LYS19
M	LYS58
M	HIS66

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Involved in GAG binding and receptor binding

Chain	Residue	Details
M	ARG24
M	LYS49

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269\|PubMed:1661560, ECO:0000269\|PubMed:2648385

Chain	Residue	Details
M	GLN1

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
M	ASN14

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)