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4DK7

Crystal structure of LXR ligand binding domain in complex with full agonist 1

Summary for 4DK7
Entry DOI10.2210/pdb4dk7/pdb
Related4DK8
DescriptorOxysterols receptor LXR-beta, Nuclear receptor coactivator 1, N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylbenzenesulfonamide, ... (6 entities in total)
Functional Keywordsligand binding domain, nuclear hormone receptor, transcription-peptide-agonist complex, transcription/peptide/agonist
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus (Potential): P55055
Nucleus (By similarity): Q15788
Total number of polymer chains4
Total formula weight61850.01
Authors
Piper, D.E.,Xu, H. (deposition date: 2012-02-03, release date: 2012-03-21, Last modification date: 2012-05-09)
Primary citationKopecky, D.J.,Jiao, X.Y.,Fisher, B.,McKendry, S.,Labelle, M.,Piper, D.E.,Coward, P.,Shiau, A.K.,Escaron, P.,Danao, J.,Chai, A.,Jaen, J.,Kayser, F.
Discovery of a new binding mode for a series of liver X receptor agonists.
Bioorg.Med.Chem.Lett., 22:2407-2410, 2012
Cited by
PubMed: 22406115
DOI: 10.1016/j.bmcl.2012.02.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

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