4DK7
Crystal structure of LXR ligand binding domain in complex with full agonist 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Oxysterols receptor LXR-beta | polymer | 247 | 28810.1 | 2 | UniProt (P55055) Pfam (PF00104) In PDB | Homo sapiens (human) | Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor |
| 2 | B, D | Nuclear receptor coactivator 1 | polymer | 12 | 1531.7 | 2 | UniProt (Q15788) In PDB | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 3 | A, C | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylbenzenesulfonamide | non-polymer | 413.3 | 2 | Chemie (0KS) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | A, C | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) | |||
| 6 | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A, C: 219 - 461 (UniProt: P55055)
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | EXPRESSION TAG |
| Ser 216 | - | EXPRESSION TAG |
| His 217 | - | EXPRESSION TAG |
| Mse 218 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60683.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1166.3 | |
| All* | Total formula weight | 61850.0 |
