4DG1
Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A
Summary for 4DG1
Entry DOI | 10.2210/pdb4dg1/pdb |
Related | 1DLO 3KLI |
Descriptor | Reverse Transcriptase P66 subunit, Reverse Transcriptase P51 subunit, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | polymorphism 172k, p51/p66, hetero dimer, aids, hiv, resistance mutations, right-hand configuration, rnase h domain, reverse transcriptase, ribonuclease h, rna-directed dna polymerase, dna polymerase, transferase, azt excision, azt unblocking, nevirapine, efavirenz, azt, nucleoside inhibitors, nonnucleoside inhibitors, nrti, nnrti |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114632.33 |
Authors | Tu, X.,Kirby, K.A.,Marchand, B.,Sarafianos, S.G. (deposition date: 2012-01-24, release date: 2012-06-20, Last modification date: 2023-09-13) |
Primary citation | Hachiya, A.,Marchand, B.,Kirby, K.A.,Michailidis, E.,Tu, X.,Palczewski, K.,Ong, Y.T.,Li, Z.,Griffin, D.T.,Schuckmann, M.M.,Tanuma, J.,Oka, S.,Singh, K.,Kodama, E.N.,Sarafianos, S.G. HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors. J.Biol.Chem., 287:29988-29999, 2012 Cited by PubMed: 22761416DOI: 10.1074/jbc.M112.351551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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