4DG1
Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse Transcriptase P66 subunit | polymer | 549 | 63202.2 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 (HIV-1) | |
| 2 | B (B) | Reverse Transcriptase P51 subunit | polymer | 427 | 49911.4 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 (HIV-1) | |
| 3 | C, D, E, R (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | F, G, K, L, N... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 5 | H, I, J, M, W... (A, B) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | AA, BA (A, B) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A: 1 - 549 (UniProt: P03366)
B: 1 - 427 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Ala 172 | Lys 771 | engineered mutation |
| Ala 173 | Lys 772 | engineered mutation |
| Ser 280 | Cys 879 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 113113.6 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 1518.7 | |
| All* | Total formula weight | 114632.3 |
