Crystal structure of the tetramerisation domain of human CtIP

Summary for 4D2H

DescriptorRBBP8, SULFATE ION (3 entities in total)
Functional Keywordsgene regulation, ctip/rbbp8, double-strand dna break repair, dna-end resection, gene conversion, homologous recombination
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains8
Total molecular weight37442.76
Davies, O.R.,Sun, M.,Pellegrini, L. (deposition date: 2014-05-09, release date: 2015-01-14, Last modification date: 2019-10-23)
Primary citation
Davies, O.R.,Forment, J.V.,Sun, M.,Belotserkovskaya, R.,Coates, J.,Galanty, Y.,Demir, M.,Morton, C.R.,Rzechorzek, N.J.,Jackson, S.P.,Pellegrini, L.
Ctip Tetramer Assembly is Required for DNA-End Resection and Repair.
Nat.Struct.Mol.Biol., 22:150-, 2015
PubMed: 25558984 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.2937
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26710 0.8% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25