4CYQ

Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 45).

Summary for 4CYQ

Entry DOI	10.2210/pdb4cyq/pdb
Related	4CYN 4CYO 4CYP
Descriptor	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-{2-chloro-5-[(3S,4R)-1-[(3R)-4-(4-chlorophenyl)-3-hydroxybutanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]phenyl}-2-(4-fluorophenyl)acetamide, ... (5 entities in total)
Functional Keywords	transferase, myristoylation, drug design, inhibitor
Biological source	LEISHMANIA MAJOR
Total number of polymer chains	1
Total formula weight	49071.78
Authors	Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Waugh, T.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2014-04-14, release date: 2014-10-01, Last modification date: 2014-11-05)
Primary citation	Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Wright, M.H.,Waugh, T.M.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors. J.Med.Chem., 57:8664-, 2014 Cited by PubMed: 25238611 DOI: 10.1021/JM5011397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation