4CYO

Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 21).

4CYO の概要

• エントリーDOI: 10.2210/pdb4cyo/pdb
• 関連するPDBエントリー: 4CYN 4CYP 4CYQ
• 分子名称: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-{5-[(3S,4R)-1-[(3R)-3-amino-4-(4-chlorophenyl)butanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]-2-chlorophenyl}-2-(4-fluorophenyl)acetamide, ... (5 entities in total)
• 機能のキーワード: transferase, myristoylation, inhibitor, drug design
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49070.79

構造登録者

Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Waugh, T.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. (登録日: 2014-04-14, 公開日: 2014-10-01, 最終更新日: 2024-05-08)

• 主引用文献: Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Wright, M.H.,Waugh, T.M.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W.; Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors.; J.Med.Chem., 57:8664-, 2014; PubMed: 25238611; DOI: 10.1021/JM5011397

実験手法

X-RAY DIFFRACTION (1.5 Å)